Instruction Set Architecture - ISA refers to the actual programmer-visible machine interface such as instruction set, registers, memory organization and exception handling. Two main approaches: RISC and CISC architectures.
A computer organization and computer hardware are two components of the implementation of a machine.  Computer organization includes the high-level aspects of a design, such as the memory system, the bus structure, and the design of the internal CPU (where arithmetic, logic, branching and data transfers are implemented).
Computer hardware refers to the specifics of a machine, included the detailed logic design and the packaging technology of the machine. For many years the interaction between ISA and implementations was believed to be small, and implementation issues were not a major focus in designing instruction set architecture. 
In the 1980’s, it becomes clear that both the difficulty and inefficiency of pipelining could be increased by instruction set architecture complications.   _{Your Comment}